Press release
Tuesday, January 3, 2023
NIH findings may provide early clues to increased risks of advanced biological aging and premature death.
According to a National Institutes of Health study published in eBioMedicine.
Using health data collected from 11,255 adults over a 30-year period, the researchers analyzed the links between serum sodium levels – which increase when fluid intake decreases – and various health indicators. They found that adults with serum sodium levels in the upper part of a normal range were more likely to develop chronic diseases and show signs of advanced biological aging than those with serum sodium levels in the middle ranges. Adults with higher levels were also more likely to die at younger ages.
“The results suggest that proper hydration can slow aging and prolong a disease-free life,” said Natalia Dmitrieva, Ph.D., study author and researcher in the Cardiovascular Regenerative Medicine Laboratory at the National Heart, Lung, and Blood Institute (NHLBI), which is part of the NIH.
The study expands on research published by scientists in March 2022, which found links between higher ranges of normal serum sodium levels and increased risk of heart failure. Both findings come from Risk of atherosclerosis in communities (ARIC), which includes sub-studies involving thousands of black and white adults from across the United States. The first ARIC substudy began in 1987 and helped researchers better understand risk factors risk factors heart disease, while developing clinical guidelines for its treatment and prevention.
For this latest analysis, the researchers assessed information shared by study participants during five medical visits – the first two when they were in their 50s and the last when they were between 70 and 90 years old. To allow a fair comparison between the correlation between hydration and health outcomes, the researchers excluded adults who had high serum sodium levels at baseline checks or with underlying conditions, such as obesity, which could affect serum sodium levels.
They then assessed the correlation between serum sodium levels and biological aging, which was assessed using 15 health markers. This included factors, such as systolic blood pressure, cholesterol, and blood sugar levels, which provided insight into how each person’s cardiovascular, respiratory, metabolic, renal, and immune systems are functioning. They also adjusted for factors such as age, race, biological sex, smoking status and hypertension.
They found that adults with higher levels of normal serum sodium – with normal ranges between 135 and 146 milliequivalents per liter (mEq/L) – were more likely to show signs of faster biological aging. This was based on indicators such as metabolic and cardiovascular health, lung function and inflammation. For example, adults with serum sodium levels greater than 142 mEq/L had an associated 10-15% increased likelihood of being biologically older than their chronological age compared to ranges between 137-142 mEq/L , while levels above 144 mEq/L were correlated with a 50% increase. Similarly, levels of 144.5 to 146 mEq/L were associated with a 21% increased risk of premature death compared to ranges between 137 and 142 mEq/L.
Similarly, adults with serum sodium levels above 142 mEq/L had an associated up to 64% increased risk of developing chronic diseases such as cardiac arrest, stroke, atrial fibrillation and peripheral artery discomfortas well as chronic lung disease, Diabetesand dementia. Conversely, adults with serum sodium levels between 138 and 140 mEq/L had the lowest risk of developing chronic disease.
The results do not prove a causal effect, the researchers noted. Randomized controlled trials are needed to determine whether optimal hydration can promote healthy aging, prevent disease, and lead to a longer life. However, associations can still inform clinical practice and guide personal health behaviors.
“People with serum sodium of 142 mEq/L or higher would benefit from having their fluid intake assessed,” Dmitrieva said. She noted that most people can safely increase their fluid intake to the recommended levels, which can be done with water as well as other liquids, such as juices, or vegetables. and fruits with high water content. the National Academies of Medicinefor example, suggest that most women consume about 6-9 cups (1.5-2.2 liters) of fluids per day and for men, 8-12 cups (2-3 liters).
Others may need medical advice due to underlying health conditions. “The goal is to make sure patients are getting enough fluids, while evaluating factors, such as medications, that may be causing fluid loss,” said study author Manfred Boehm, MD, and study director. Cardiovascular Regenerative Medicine Laboratory. Doctors may also have to defer to a patient’s current treatment plan, such as limiting fluid intake for heart failure.
The authors also cited research that finds that about half of people worldwide do not meet the recommendations for the daily total. the water intake, which often starts at 6 cups (1.5 liters).
“On a global level, this can have a big impact,” Dmitrieva said. Decreased body water content is the most common factor that increases serum sodium, so findings suggest that proper hydration can slow the aging process and prevent or delay chronic disease.
This research was supported by the Division of Intramural Research of the NHLBI. The ARIC study was supported by research contracts from the NHLBI, NIH, and the Department of Health and Human Services.
About the National Heart, Lung, and Blood Institute (NHLBI): NHLBI is the world leader in conducting and supporting research into heart, lung and blood diseases and sleep disorders that advances scientific knowledge, improves public health and saves lives. For more information, visit www.nhlbi.nih.gov.
About the National Institutes of Health (NIH):The NIH, the national agency for medical research, comprises 27 institutes and centers and is part of the US Department of Health and Human Services. The NIH is the principal federal agency conducting and supporting basic, clinical, and translational medical research, and it studies the causes, treatments, and cures for common and rare diseases. For more information about the NIH and its programs, visit www.nih.gov.
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To study
Dmitrieva NI, Gagarin A, Liu D, et al. High normal serum sodium in middle age as a risk factor for accelerated biological aging, chronic disease, and premature mortality. eBioMedicine. 2023. do: 10.1016/j.ebiom.2022.104404.
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